The hbv core protein produced during hbv replication is used to a form a capsid, inside the capsid containing the pgrna, reverse
transcription takes place. NVR 3-778 disrupts the formation of the capsid, without a properly formed capsid, new virion cannot be replicated. TDF/ETV inhibit reverse-transcription taking place inside the capsid. So all of them target the replication process. If successful, it will lead to reduction of hbvdna in the serum.
Just my layperson understanding.