Starts with poppy-based raw material (codeine, morphine, thebaine) and chemically alter these in the lab to come up with hydromorphone, hydrocodone, <span style = 'background-color: #dae8f4'>oxycodone</span>
, <span style = 'background-color: #dae8f4'>oxymorphone</span>
, desomorphine, diacetylmorphine (heroin), etc.
Opioid, fully synthetic: Fentanyl, pethidine, methadone, tramadol, dextropropoxyphene, buprenorphine (suboxone), etc. Created in lab with no need for raw material derived from the poppy. Many derived from petroleum.