Oxymorphone metabolites

Common Questions and Answers about Oxymorphone metabolites

opana

I've just been switched from Fentanyl 25mcg every 48 hrs to Oxymorphone 10mg every 12hrs. I feel way worse (pain) & was wondering if anyone knows what the equivalence is between the 2. I have a feeling I've just been decreased in pain relief. My dr & the pharmacist told me to wait a few days to "feel it's working" & in the meantime I'm in excruciating pain. Can anyone help with what I can do here? Btw...I've had chronic pain for 6 yrs & I've been rx'd almost everything.
When oxycodone metabolizes, it leaves 15% as oxymorphone. Because oxymorphone has a longer half life than oxycodone, it is often present in the urine after oxycodone falls below the detection threshold. See PPM for more info: http://www.practicalpainmanagement.
When you test for drugs you are testing for the metabolites the body breaks the drug into. For instance, oxycodone is metabolized into oxymorphone before it reaches the brain. Heroin is metabolized into morphine, these are one of the metabolites looked for in drug tests.Levmetamfetamine ( in vicks inhalers) can cause a false pos. for methamphetamine.
Result Code Result Name LOINC Code Component Name 82000000 Amphetamines 3349-8 Amphetamines 82000010 Amphetamine 19346-6 Amphetamine 82000020 Methamphetamine 3780-4 Methamphetamine 82000030 Barbiturates 3377-9 Barbiturates 82000040 Amobarbital 11230-0 Amobarbital 82000050 Butalbital 11071-8 Butalbital 82000060 Pentobarbital 3926-3 Pentobarbital 82000070 Phenobarbital 3950-3 Phenobarbital 82000080 Secobarbital 19
It is spelt Codeine,and it really sucks,get the Hydrocodone or Dihydrocodeine,or the oxycodone or maybe oxymorphone,then again why not morphine?.Codeine makes me SICK.Did you know that even though Codeine is a "Natural" Opioid all of the Medical Supplies are actually made by Methylating Morphine in a Pharmaceutical laboratory(not exactly natural)is it then?. Go the Morphine,kill to get it if you have to,well maybe a few Opium Poppies anyway.
Another common mishap is that chronic pain patients test positive for hydromorphone (dilaudid) when they are taking vicodin or they test positive for oxymorphone (opana) when they are taking oxycodone. This is because hydromorphone and oxymorphone are the metabolites of hydrocodone and oxycodone, respectively. The liver produces these metabolites in trace amounts and depending on the the threshold of the urine test, many have been labeled with false positives of these opioids.
I had a close relative on the patch and she was give oxymorphone suppositories until the patch started to work. (she suffered cancer pain) The other question was in reference to a long acting opiate. There a few short acting opiates that are in a slow release formulation,but they have all the disadvantages of short acting opiates. These medicines IMO are very good pain relievers but they are very disturbing to the endorphin neurtransmiters.
Oxycodone, oxymorphone (Opana), hydrocodone (opioid in Vicodin) and other less common ones are semi-synthetic, derived in part from thebaine (a small part of what is in natural opium). The only true synthetics that are common for us with chronic pain are the fentanyl family (Fentanyl, Sufentanil, Alfentanil, etc.) and methadone, which are come from very different chemical processes. The chemistry is not too complicated, if you have any background in it.
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