Oxycodone vs hydromorphone

Common Questions and Answers about Oxycodone vs hydromorphone


My dr took me off 30mg oxycodone ir and replaced it with 10mg opana ir, because my tolerance to oxycodone was too high. I have been on opana a few days now, and I am doinh pretty well (none of these meds completely relieve my back pain even after several surgeries) but I would say trust in your dr, and if what he is doing doesnt help, let him know as soon as you can.
So, if you compare oral Dilaudid to Oxycodone, without question, Dilaudid(Hydromorphone)IR is less addictive than Oxycodone IR(Percocet). Even correct dosage of Oxycodone produces ''Morphine-like'' Euphoria With that said; Dilaudid(Hydromorphone) is more than twice as potent as Oxycodone and if a person injects Hydromorphone it too is highly addictive! Oxymorphone seems to be somewhere in between the two...
I do not know of any evidence that hydromorphone is better tolerated overall than oxycodone.
I'm not a doctor, so keep that in mind. Mg for mg, hydromorphone is definitely stronger than oxycodone. It is hard to figure out exactly because you really need to add in a cross-tolerance when comparing the two and that varies person to person. If you use the lowest "medically acceptable" cross tolerance, 10mg of oxycodone (not long acting) is equal to about 3mg of hydromorphone (again, not the long acting type).
That' sall well and good, but I know for a fact that I feel much differently when taking one vs. the other. Maybe he was handing me a line.
He wouldn't return any of my calls so I went to the emergency room for withdrawal. They gave me Antibiotics, an in-haler, and OXYCODONE, till I could get back with my Doctor. Crap!, I didn't even want the Oxycodone, just the cough syrup. I've had Hydrocodone pills from Dentist visits lying around for years that I never took, till I found out that it was the hydrocodone and no other substance, that was suppressing the urge to cough.
I think there is a misconception out there that 50 mg of painkiller A is equivalent to 50 mg of painkiller B in terms of potency, half-life, withdrawal, etc. This is just not true. The quantity matters when making comparisons, as does the method of administration (oral vs injected vs snorted vs smoked). Just google "equianalgesic table" and you will see what I mean.
For some people oxycodone keeps them up at night, others can take a small amount and feel drowsy. I don't know much about the extended-release hydromorphone, or hydromorphone ER. I've never taken it. I am taking 4 mgs of dilaudid as a substitute for oxycodone 30mg and I don't feel it works very well. I am also slightly more tired on the dilaudid than i was on the oxycodone. Part of my problem is it just never really takes the pain away in a significant amount.
Basically it's for people who have already been taking something like oxycodone daily or hydromorphone daily and they've started to get break-through pain with those medications, so they need something stronger and something long-lasting. But, since fentanyl is so strong, much stronger than morphine, oxycodone, or even hydromorphone...
The medicine is called roxicodone and the mgs of oxycodone go up to I think 30 mg per pill vs. 5 mg per pill. Keep in mind that many have testified that oxycodone works better with the acetaminophen (i.e., percocet) than without even though the amount of oxycodone has been increased because the tylenol adds a synergistic effect which aids increased pain relief. So you may find if you take a little over the counter tylenol with the roxicodone, that you get increased pain relief.
I actually stumbled upon this site while using, by doing a search of 'oxycodone VS hydromorphone'.....my drugs of choice. It probably won't take your friend long to realize, that this is a one way ticket to shitsville!!! That realization COULD be the catalyst he needs. I sympathize with your situation, having been through it more than once myself; and clearly he is lucky to have such a caring friend.
It is oxymorphone and it is strongest pain medication available in pill form based on pharmacology. The oxycodone in Oxycontin is metabolized by the liver into oxymorphone. Therefore, the Opana ER would be a drug that is very comparable to the Oxycontin, only twice as strong.
medication specifically for IC, meds for bladder urgency, meds for anti-depression and pain meds---vicodin--percs---oxycodone and contin---hydromorphone, whatever. I have also underwent 3 hydro-distention procedures and most recently I had a temporary electrical device placed in my back and I was able to control the impulses. None of these have worked. Now my uro want to surgically implant the interstim permanantly in my lower back and again I would control the electrical impulses.
Neither embryo-fetal toxicity nor teratogenic effects were observed following administration of DILAUDID at oral doses up to 7 mg/kg/day (41 mg/m 2 ) in rats from day 6 to day 17 of gestation and up to 25 mg/kg/day (315 mg/m 2 ) in rabbits from day 6 to day 20 of gestation. Literature reports of hydromorphone hydrochloride administration to pregnant Syrian hamsters show that DILAUDID is teratogenic at a dose of 20 mg/kg which is 600 times the human dose.
I have recently been referred to a new pain management doc and he is in the process of adding/switching me over to Kadian for long-acting pain control vs. just the Norco I have been on....my question primarily is how long will it take for me to adjust to the change from short acting opiate to the extended release meds...
Of course the choice is yours. I would just want to take something when I don't feel well vs all the time. There is an oxycodone with no tylenol. Methadone is a very good pain reliever I know people who are on it and people here who treated and were on it. It did help, it is just that normally a doctor will try other pain meds first before going on to methadone. Good luck Hang in there, it does get better.
30mg Oxycodone (8) Hydromorphone (9+) Morphine (5) Heroin (6-) Hydrocodone (4) Codeine (1-) IV studies: 10mg Oxycodone (8.5+) Heroin(3,6-Diacetylmorphine) (9+) Morphine (7) Hydrocodone (7.5+) Hydromorphone (10) Codeine (0+) NOTE 1.these studies are not demonstrative of Analgesic effects ONLY Euphoria and subsequent propensity to re-administer in the particular individuals selected in the actual doses used. NOTE 2.the rating between oral and IV are relative(globally).
Starts with poppy-based raw material (codeine, morphine, thebaine) and chemically alter these in the lab to come up with hydromorphone, hydrocodone, oxycodone, oxymorphone, desomorphine, diacetylmorphine (heroin), etc. Opioid, fully synthetic: Fentanyl, pethidine, methadone, tramadol, dextropropoxyphene, buprenorphine (suboxone), etc. Created in lab with no need for raw material derived from the poppy. Many derived from petroleum.
I don't believe these doctors are truthful. I talked at EVERY appointment about dependence vs. tolerance vs. addiction. One doctor told me I COULDN'T get addicted since I was treating pain. Right. I'm starting to think pain management is a cash cow and they don't even want me to taper down. My medication comes to a little over $3,000 a month. Someone's making money.
That is something many of us have experienced first hand, and is one of the many wonderful(NOT) side effects of oxycodone, and opiates in general. Hell i remember if someone even looked at me funny at the grocery store, i was ready to clobber them; and truth is they were probably just going to say hi. As far as other side effects, well of course there is the liver which you mentioned and the kidneys.
For example, people taking morphine, hydromorphone, or oxycodone may experience withdrawal symptoms within 6 to 12 hours of the last dose while people taking methadone will experience symptoms 3 to 4 days after the last dose. How many symptoms you experience, how long you experience them, and how severe your symptoms are depends on your body’s individual response, how long you’ve been taking the medications and the dose and type of opioid.
Vicodin(lortab,hydro.) are weak painkillers. Oxycodone, morphine, hydromorphone, demerol,etc.
Now my only hope is a pain treatment clinic, and if they won't prescribe methadone for me there, then I'll have to detox off of oxycontin from my doctor (he is allowed to give me oxycontin or hydromorphone etc., but not methadone!). Going to a methadone clinic again would mean being a "prisoner-client" forced to take a huge dose of methadone to hold me 24hours.
A while back I posted a topic on Morphine Vs Negative Drug screen. It has some very informative info and also explains why the tests can come out negative. Scroll down a few pages and you'll find it or PM Beargizmo, I sent it to him.
I used pain meds for nearly 3 weeks, post TKR, gradually extending the time between pills and then from 2 pills to 1 (Oxycodone). Since then I've been taking 2 acetaminophens 3 or 4 times a day. I also take 2 200mg celebrex a day and have for the past 2 yrs and will continue through the next TKR and left Rotator Cuff repair which is tenatively scheduled for mid July. I Had the right shoulder cuff reapaired in January.
This led to me getting a Neurologist who prescribed me oxycodone. That just meant I started taking them together, going through 120 oxy's in a week. If I run out and am left tramadolless for a day, I can not function in public, ie I am a mess per withdrawel symptoms listed above. I will not attend anything, no matter how important, if I don't have tramadol. Anyway, this drug needs more awareness amongst the FDA and doctors in general. I would schedule it with morphine.
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