Most commonly, generalized
osteoarthritis occurs
in the spine, knees, hips, base of the thumb
in the first CMC (carpometacarpophalangeal joint), tips of the fingers, and big toe. The wrists, elbows, and shoulders are typically not involved in generalized osteoarthritis.
Other Facts About Generalized Osteoarthritis
A gene defect that causes primary generalized osteoarthritis has been discovered.
Generalized osteoarthritis develops spontaneously.