oseltamivir resistance during treatment

However, no adverse effects have been reported among women who received oseltamivir or zanamivir during pregnancy or among infants born to women who have received oseltamivir or zanamivir. Pregnancy should not be considered a contraindication to oseltamivir or zanamivir use. Pregnant women might be at higher risk for severe complications from swine influenza, and the benefits of treatment or chemoprophylaxis with zanamivir or oseltamivir likely outweigh the theoretical risks of antiviral use.

Recommended duration of treatment is five days, and for chemoprophylaxis is 10 days. Oseltamivir and zanamivir treatment and chemoprophylaxis regimens recommended for pregnant women are the same as those recommended for adults who have seasonal influenza. Recommendations for use of antivirals for pregnant women might change as additional data on the benefits and risks of antiviral therapy in pregnant women become available.

htm Hepatotoxicity Despite widespread use, there is little evidence that oseltamivir when given orally causes liver injury, either in the form of serum enzyme elevations or clinically apparent liver disease. A proportion of patients with acute influenza A may have minor serum enzyme elevations during the acute illness, but these appear to be independent of therapy and are not exacerbated by osteltamivir.

No. The new STAT-C meds can be used in combination with SOC drugs (peginterferon & ribavirin) for those who previously failed SOC treatment and want to try again to achieve SVR. These patients will have a better chance of SVR with the new meds.

Thanks for your response. To clarify: his treatment was adjunctive. At the time they saw no sign of cancer outside the lung. Now, however, after 4 rounds of chemotherapy the disease seems to have spread during treatment with taxotere and cisplatin: it's now in the liver, bones and adrenal glands. His original tumor was EGFR positive that is why Tarceva came up as a viable second step.

"Try Truvada. There are reports that it clears surface antigen at 11% per year. The benefit of interferon still will be there as it had a long lasting effect." - do you have this reports ? "Five years ago they were right on the spot with Baraclude saying it is weak drug and resistance issue will be a problem with HBV..

hi my friend had unprotected vaginal intercourse with a CSW , after three months he did Hiv-1,2 antibody combo test i came back with negative , but one week before he had influenza b positive , for this one he took oseltamivir tablet 75 mg tablet 9 nos for 5 days , these tablets can affect the test result? Kindly confirm he needs to check again three months antibody test is conclusive.

The therapy had been switched to adefovir and then to entecavir when breakthrough occcured during each treatment. This led only to a temporary HBV DNA decline which soon was followed by viral breakthrough despite the lack of known entecavir resistance mutations. Patient died after 9 months of entecavir treatment from liver failure. A total of 434 clones from 6 different serum samples were analysed retrospectively.

You want to minimize risk for resistance since you may need life-long treatment. Combo trreatment will offer a higer genetic barrier against resistance, which is what need to be considered for long term treatment. Also, with that high VL, you should be on the Entecavir 1mg instead of the 0.5mg. The goal should be to drop the VL as qucikly as possible. Good luck.

Antiviral therapy may be used during pregnancy to control maternal disease. Data are lacking on TDF treatment throughout pregnancy in mothers with active chronic hepatitis B (CHB). We evaluate the safety and efficacy of TDF therapy in such mothers and their infant outcomes. Methods: We retrospectively enrolled CHB mothers who received TDF (300 mg/day) throughout their pregnancy between 1/2011-5/2013 and assessed mother-infant outcomes. All infants received appropriate immunoprophylaxis.

Futility Rules and Prevention of Resistance Viral resistance with boceprevir and telaprevir occurs because of the selection of preexisting variants during the course of therapy, as a result of failure to eradicate infection on triple combination treatment.

t find a lot of information online on treatment during pregnancy, but she told me there has been studies and it's safe. The other thing that I'm scared about is breastfeeding after giving birth. I am told that it is okay to breastfeed even if you are HBV positive. My concern is this; I did some research and found that it is not good to stop medication, which is what I thought I would do after giving birth so that I can breastfeed.

stevenNYer is pretty knowledgeable about treatment drugs and treatment in general. Questions: What is your wife's disease history? What is your wife's e-antigen status? How old is she? Does the doctor have an endpoint for treatment?

Another appropriate time to alter therapy by switching or adding another drug to the treatment regimen is when there is development of HBV antiviral drug resistance. Treatment with adefovir is associated with a 29% rate of resistance in HBeAg-negative patients after 5 years of therapy. Entecavir is associated with one of the lowest cumulative rates of resistance in treatment-naive patients, < 1% after 4 years of therapy.

Recommendations recently developed by the HCV Drug Resistance Advisory Group emphasize the value of resistance testing at treatment baseline and failure in support of the development and clinical evaluation of new drug candidates. In HIV, the routine use of resistance testing to guide antiviral drug treatment is established in clinical practice.

Pioglitazone was safe and well tolerated during the study. Weight gain and edema were more frequent in the treatment group. http://www.medicalnewstoday.com/articles/110717.

Is insulin resistance a reason for failing to clear the virus after treatment and if it is , how can I treat the insulin resistance? Can Interferon cause Insulin Resistance? 13 years post treatment I feel worse than ever and I do not beleive it is solely the virus.

Here is a great talk with audio and slide presentation from "The Best of The Liver Meeting® 2010 Postgraduate Course sessions" The doctor explains viral resistance and how treatment with DAAs works with peg-interferon and ribavirin. Therapy of Hepatitis C: Viral Resistance and Remaining Challenges http://74.43.177.57/courses/2010/pg/pawlotsky/player.html Cheers!

//www.medhelp.org/user_journals/show/68011?personal_page_id=450 http://www.medhelp.org/user_journals/show/71197?

LAM mutations are present even naturally and if you happen to have it etv is wrong i had a secondary mutation (not resistance) from lam and adv naturally before starting treatment and since test detects these mutations when higer than 20% other mutations might be present but not detected....so this is way combo is very important anyway.

Author information Abstract Tenofovir disoproxil fumarate (TDF) is widely used to treat hepatitis B virus (HBV) patients in the USA and Europe. No confirmed report of resistance selection during treatment with TDF in treatment-naïve and nucleoside / nucleotide analog-treated chronic hepatitis B patients has yet been reported.

Oseltamivir resistance during treatment

Common Questions and Answers about Oseltamivir resistance during treatment

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