Oseltamivir pharmacokinetics

Common Questions and Answers about Oseltamivir pharmacokinetics

tamiflu

938718 tn?1323783514 However, no adverse effects have been reported among women who received oseltamivir or zanamivir during pregnancy or among infants born to women who have received oseltamivir or zanamivir. Pregnancy should not be considered a contraindication to oseltamivir or zanamivir use. Pregnant women might be at higher risk for severe complications from swine influenza, and the benefits of treatment or chemoprophylaxis with zanamivir or oseltamivir likely outweigh the theoretical risks of antiviral use.
566175 tn?1278430472 Treatment and chemoprophylaxis The currently circulating swine influenza A (H1N1) virus is sensitive to the neuraminidase inhibitor antiviral medications zanamivir and oseltamivir, but is resistant to the adamantane antiviral medications, amantadine and rimantadine. Pregnant women who meet current case-definitions for confirmed, probable or suspected swine influenza A (H1N1) infection should receive empiric antiviral treatment.
Avatar n tn - Absorption, oral: time to peak concentration 7h - Elimination half-life = 12 h (It says also that in general it can be administered once daily because it has a 24 h effect.Why?) - Can you give another example to clarify it better please? - When it says divide in 2 doses , does it mean only in the morning and dinner? 3 doses (morning-lunch-dinner)? Thank you for taking the time to answer!!
Avatar n tn hi my friend had unprotected vaginal intercourse with a CSW , after three months he did Hiv-1,2 antibody combo test i came back with negative , but one week before he had influenza b positive , for this one he took oseltamivir tablet 75 mg tablet 9 nos for 5 days , these tablets can affect the test result? Kindly confirm he needs to check again three months antibody test is conclusive.
11062655 tn?1414987783 htm Hepatotoxicity Despite widespread use, there is little evidence that oseltamivir when given orally causes liver injury, either in the form of serum enzyme elevations or clinically apparent liver disease. A proportion of patients with acute influenza A may have minor serum enzyme elevations during the acute illness, but these appear to be independent of therapy and are not exacerbated by osteltamivir.
Avatar m tn I can't help out on the pharmacokinetics, but your reasoning is sound: it doesn't make sense to dose so that the drug runs out. I'd query Schering-Plough as well as your hepatologist, if I were you. Please give me a heads-up if you solve the riddle.
7510956 tn?1411671417 //www.fda.gov/downloads/advisorycommittees/committeesmeetingmaterials/drugs/antiviraldrugsadvisorycommittee/ucm375286.
Avatar f tn s sudden appearance might have been a side effect of TAMIFLU which is now known to rich (oseltamivir substance) the blood-brain barrier and cause irreversible dammages to brain. As a conclusion, TAMIFLU appeared to be responsable of a "medecinal intoxication" causing the narcolepsy-cataplexy I suddenly suffer since then. Several Years after, we hear about narcolepsy cases caused by the massive H1N1 vaccinations...
372366 tn?1284403873 Copyman, I think we have a rhyme for teleprivir now). Ribavirin is not one of those listed. But being a suspicicious person, I have a theory of why riba is not a suggest 'stockpiled' anti-viral. If governments and business were to create significant stockpiles of ribavirin they could be accused of accumulating weapons of mass destruction. And we all know what that could cause.
Avatar m tn Hepatic Impairment In volunteers with hepatic impairment (Child-Pugh Class A and B), sildenafil clearance was reduced, resulting in higher plasma exposure of sildenafil (47% for Cmax and 85% for AUC). The pharmacokinetics of sildenafil in patients with severely impaired hepatic function (Child-Pugh Class C) have not been studied. A starting dose of 25 mg should be considered in patients with any degree of hepatic impairment [see Dosage and Administration (2.5) and Clinical Pharmacology (12.3)].
Avatar f tn Folic acid supplementation in folate-deficient patients with epilepsy changes the pharmacokinetics of phenytoin, usually leading to lower serum phenytoin concentrations and possible seizure breakthrough..." It however says that initiation of Folic acid and phenytoin together is beneficial. Since you can't go back and start all over again, you can take a small dose. It has been observed that as los as 1mg dose can perturb phenytoin’s levels, You may take doses lower than 1mg/day.
863754 tn?1239144755 However, physiological changes resulting from smoking cessation may alter the pharmacokinetics or pharmacodynamics of insulin; dosage adjustments may be necessary.
Avatar m tn The Phase 1 trial was designed to characterize the safety profile of ARC-520 across a range of doses and evaluate pharmacokinetics. It is a single-center, randomized, double-blind, placebo-controlled, single dose-escalation, first-in-human study of ARC-520 administered intravenously to healthy adult volunteers. All subjects have been dosed and received either placebo or ARC-520 in doses ranging from 0.01 mg/kg to 2 mg/kg.
Avatar f tn i believe in the pre-clinical trials with healthy volunteers, researchers used Carbon14 to gauge the half-life and paths of elimination during pharmacokinetics studies. it is a common practice. perhaps that is what you are thinking about?
29837 tn?1414534648 The pharmacokinetics of ledipasvir were studied with a single dose of 90 mg ledipasvir in HCV negative subjects with severe hepatic impairment (Child-Pugh Class C). Ledipasvir plasma exposure (AUC0-inf) was similar in subjects with severe hepatic impairment and control subjects with normal hepatic function. Population pharmacokinetics analysis in HCV-infected subjects indicated that cirrhosis had no clinically relevant effect on the exposure of ledipasvir [see Use in Specific Populations (8.
Avatar m tn if any family members are aged, frail, or have other underlying illnesses, s/he definitely should see a doctor. They may be candidates for oseltamivir (Tamiflu), which speeds recovery and helps prevent complications. Also, even healthy or strong individuals benefit it started early -- anyone who is just starting to become ill (within 2-3 days) should see the doc.
808353 tn?1238293321 The combination of two potent direct-acting antivirals (DAAs), targeting two distinct viral enzymes, may offer advantages over single DAA strategies by enhancing potency, reducing the emergence of drug resistance, and possibly eliminating the need for PEG-IFN +/- ribavirin. The combination of R7128/R7227 offers the potential for a highly potent regimen with a high genetic barrier to resistance. Methods: INFORM-1 is a randomized, double-blind, ascending dose Phase I trial.
Avatar m tn Nitazoxanide, brand name alinia, had also excellent ed50 results in an in vitro inhibition study, just as good as lamuvidine, so this sounded fascinating for a possible combination towards true synergism, to finally suppress virion production to a level so low that the silent daily reinfection will be reduced, allowing a slow net clearance of infected cells with a resulting drop in surface antigen.
Avatar n tn Completely absorbed from the GI tract. Sodium salt (Anaprox) is more rapidly absorbed. Distribution: Crosses the placenta; enters breast milk in low concentrations. Protein Binding: >99%. Metabolism and Excretion: Mostly metabolized by the liver. Half-life: 10–20 hr. CONTRAINDICATIONS AND PRECAUTIONS Contraindicated in: Hypersensitivity Cross-sensitivity may occur with other NSAIDs, including aspirin Active GI bleeding Ulcer disease.