• Other anecdotal treatments include vitamin E, levodopa, benzodiazepines, botulinum toxin, reserpine, tetrabenazine, and dopamine-depleting agents. Ondansetron
, a selective 5-hydroxytryptamine-3 antagonist, has helped some individuals with TD. Discontinuation of treatment with anticholinergics may relieve TD. A controversial strategy to treat TD is continuing and/or increasing the dose of the dopamine antagonist.