Long-
term use of Proton Pump Inhibitors can cause or exacerbate Osteoporosis, chest pain, distended stomach, nausea, diarrhea/constipation, abdominal pain, flatulence, headache & trouble swallowing. They can also interfere with the absorption of other drugs. As you can see, most of the side effects appear to be gastrointestinal, which means we have to be aware of whether our symptoms are coming from the Reflux/Barrett's, etc.