FDA is alerting the public to new safety information concerning an interaction between clopidogrel (
Plavix), an anti-clotting medication,
and omeprazole (Prilosec/Prilosec OTC), a proton pump inhibitor (PPI) used to reduce stomach acid. New data show that when clopidogrel and omeprazole are taken together, the effectiveness of clopidogrel is reduced.