Nisoldipine

Common Questions and Answers about Nisoldipine

sular

Coadministration with the hepatitis C virus (HCV) NS3/4A protease inhibitors, boceprevir and telaprevir, may increase the plasma concentrations and pharmacologic effects of calcium channel blockers, especially the dihydropyridines (e.g., amlodipine, felodipine, nicardipine, nifedipine, nisoldipine). The mechanism involves inhibition of intestinal and hepatic CYP450 3A4, the isoenzyme primarily responsible for the metabolic clearance of most calcium channel blockers.

nimodipine (Nimotop), felodipine (Nitrendipine, Plendil), nisoldipine (Sular), nicardipine (Cardene), verapamil (Verelan) Psychiatric medications: buspirone (BuSpar), triazolam (Halcion), carbamazepine (Tegretol), diazepam (Valium), midazolam (Versed), sertraline (Zoloft) Intestinal medications: cisapride (Propulsid) taken off the U.S.

sildenafil, tadalafil Hormone replacement: cortisol, estradiol, methylprednisolone, progesterone, testosterone Immunosuppressants: cyclosporine, sirolimus, tacrolimus HMG-CoA reductase inhibitors: atorvastatin, fluvastatin, lovastatin, simvastatin Opioids: alfentanil, fentanyl, sufentanil Selective serotonin reuptake inhibitors: fluvoxamine, sertraline Xanthine: theophylline

calcium channel blockers such as amlodipine (Norvasc), diltiazem (Cardizem, Dilacor, Tiazac, others), felodipine (Plendil), isradipine (DynaCirc), nicardipine (Cardene), nifedipine (Adalat, Procardia), nimodipine (Nimotop), nisoldipine (Sular), and verapamil (Calan, Covera, Isoptin, Verelan);carbamazepine (Tegretol); diuretics ('water pills'); medications for mental illness such as haloperidol (Haldol); methyldopa (Aldomet); metronidazole (Flagyl); nonsteroidal anti-inflammatory medicat

carvedilol Calcium channel blockers: diltiazem, felodipine, nicardipine, nifedipine, nimodipine, nisoldipine, verapamil Erectile dysfunction drugs: sildenafil, tadalafil Hormone replacement: cortisol, estradiol, methylprednisolone, progesterone, testosterone Immunosuppressants: cyclosporine, sirolimus, tacrolimus HMG-CoA reductase inhibitors: atorvastatin, fluvastatin, lovastatin, simvastatin Opioids: alfentanil, fentanyl, sufentanil Selective serotonin reuptake inhibitors: fluvoxamine, sertral

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