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Niacin and fibrates

Common Questions and Answers about Niacin and fibrates

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exercise, weight loss, statins and fibrates, niacin, fish oil. Even aspirin?
Bile acid binding resins, Cholesterol absorption inhibitors, Fibrates, Niacin, Omega-3, Artichoke concentrate, Exercise ...
Exercise, Niacin, Fibrates ( such as gemfibrozil) and some statins can all raise HDL. Alcohol consumption in moderation can also do this. Whereas there is a strong link between low HDL and risk for cardiac death and heart attacks, there is very little evidence that increasing it with drugs ( appart from gemfibrozil and Niacin) actually improves patient's mortality.
Hi, Cholesterol lowering drugs mainly are statins, but depending upon which lipoproteins or triglycerides are high other drugs like fibrates can be used. Other than these niacin or bile acid sequestrants can also be used for treating high cholesterol levels if you are experiencing leg pain with use of statins. Also, diet modifications under the supervision of a nutritionist can help cope with this situation. Best.
just to be sure that nobody gets taken in by the false notion that no fibrate can be combined with statins, here is the ongoing very large ACCORD trial which uses statins and fibrates together: http://www.nhlbi.nih.gov/health/prof/heart/other/accord/q_a.htm "ACCORD will continue to study the effects of intensive compared with standard treatment of blood pressure and the effects of fibrate plus statin compared with placebo plus statin.
I love my wife and don't want to create issues at home with the statins. I rather go without and accept the consequences later. So what is the possibility of the niacin helping me out?
I started back on the statins and low and behold the palps returned. Anyone that has PVC's and PAC's knows how much of a nuisance they can be both physically and emotionally. Is there any other drug that is not in the same class as statins that works on cholesterol. I already eat oatmeal, take fish oil, etc. Thanks!
According to Uptodate, the medications that cause this condition include colchicine, nondepolarizing muscle relaxers with high doses of corticosteroids, antimalarials, niacin, penicillamine, fibrates, zidovudine and statins. Drugs that can cause elevated liver enzymes include cocaine and alcohol, particularly when they are abused. Testing patients for elevated muscle enzymes helps doctors determine the cause and can help to evaluate muscle pain, weakness and inflammation.
Factors that elevate HDL concentrations include chronic alcoholism, treatment with oral estrogen replacement therapy, extensive aerobic exercise, and treatment with niacin, statins, or fibrates. On the other hand, smoking reduces levels of HDL cholesterol, while quitting smoking leads to a rise in the plasma HDL level. HALP from genetics is considered primary and HALP resulting from environmental issues is considered secondary. HALP is more prevalent in women at a rate of 7.
Prior to taking Omega 3 Fish Oil (1000mg) and Niacin (500mg) my triglyceride count was 1895 and my cholesterol was heading towards 400. I cannot use the statins or fibrates because of allergic reactions and liver problems. After just 6 weeks on the Omega 3 and Niacin, my triglycerides dropped almost 1600 points to 334 and my cholesterol dropped to 247. I was stunned and my doctor was delighted. Needless to say, I am continuing the regiment, quite happily.
pravachol) because of adverse effects (elevated liver enzymes, creatine kinase levels, muscles aches and weakness) and the fibrates (gemfebrizole)caused me to break out in hives from head to toe (lasted over a month). The new drug, Zetia, caused such severe headaches I could not move my head without excruciating pain. Niacin is counterindicated because of other medication I am on, including the above mentioned Avapro. Past blood tests (February 2003) show a CRP of 9.5.
My cholesterol is extremely high and uncontrollable due to hyperlipidemia and intolerance of statins, so I am planning for bypass within this next year. My question is, am I a candidate for the minimally invasive surgery (just based on what info I have given you, I am 54 and in fair health otherwise)? My LAD is very diseased. Also would it be possible to bypass my RCA during this kind of surgery? It is congenitally small and insignificant per the latest cath report.
They block the production of cholesterol in the liver. Other options include cholesterol absorption inhibitors, bile acid resins, and fibrates. Your doctor may recommend a combination of these medications. Treatment: Supplements Certain dietary supplements may also improve cholesterol levels. These include flaxseed oil, fish oil, and plant sterols, such as beta-sitosterol.
Other drugs such as niacin and fibrates are sometimes added to statins to try to reach those goals, but studies show they don't always lower the chances of heart problems. "Chasing numbers can lead us to using drugs that haven't been proven to help patients. You can make someone's lab test look better without making them better," said Yale University cardiologist Dr. Harlan Krumholz, who has long urged the broader risk approach the new guidelines take.
Varios pharmacologic therapies include in order of HDL efficacy (niacin, fibrates, estrogen, and statins). Caffeine can have an effect on PVCs through many of the expereices seen in others in this forum. Hypertension guidelines are related to your overall risk. Unless you have a compelling indication such as diabetes or kidney disease, generally treatment is not institued unless your BP is above 140 systolic.
Currently there is no other way than Niacin ( not for patients with liver disease!) exercise, weight loss and some fibrates to increase HDL levels. The one promising drug in development to raise HDL development, by Pfizer, after they spent ONE BILLION!! on it -Torcetrapib- was stopped a few days ago - terminated with a bang. Horrrible. After SVR you need to have your Dr. and yourself do its best to normalize the dyslipidemia by all means available.
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