Yeah, it made me more nervous, which is common with it. Taurine is much more helpful. The B-6 question depends on how much you're already getting in other supplements and your diet, but the body does need B-6 to make both serotonin and GABA. 5-HTP can work against you when you're in withdrawal, because what's happening is, serotonin receptors are waking up that the body felt weren't necessary anymore because of the reuse of serotonin by other receptors targeted by the Prozac.