nefazodone hepatotoxicity

I might have a solution for you after examining the pharmacology of Nefazodone. To get about the same result you had with Nefazodone with no weight gain I would recommend sertraline (Zoloft) combined with Wellbutrin XL. To get a significant antagonizing effect to your 5-HT2 receptors you would need mirtazapine but it is related with weight gain so I would try the Zoloft with Wellbutrin XL which will basically in a SNDRI like Nefazodone and see how it goes.

I've had chronic, severe nausea for the past year and I can't take it anymore. I get nauseated after everything I eat. It doesn't matter what. I can't even have breakfast anymore (I went from eating solids to drinking liquids, and now I can't eat anything at all). Sometimes I feel like I'm not even hungry, and other times I feel horribly hungry. I can only have small meals now and I can't have dairy or bread.

Tuberculosis was more common in alcoholic and Child class C cirrhosis (Table 1). Antituberculosis therapy (ATT) is associated with hepatotoxicity in 10%. Hepatotoxicity requires withdrawal, modification, and sequential reintroduction to achieve cure of tuberculosis. Using such hepatotoxic drugs in presence of cirrhosis or advanced liver disease is a challenge.

Although clinically significant liver injury is extremely rare from statins, mild increases in liver enzymes can occur in 1%–3% of patients. Because of the concern of possible hepatotoxicity, statins are labeled as contraindicated in patients with liver disease. Given the prevalence of liver diseases in the population, such as nonalcoholic fatty liver disease (NAFLD), hepatitis C (HCV), and others, many patients have not benefitted from the cardiovascular protective effects of statins.

Anyway, there are lots of options - ranging from a number of medications that have been well studied such as nefazodone, mirtazapine, and the tricyclic antidepressants, to supplements that seem to be effective (although probably somewhat less so) such as hypericum and s-adenosyl methionine. Finally there are a number of medications that are not routinely prescribed for depression that might be of use, and that list is a bit long to put here. In any event, the answer is yes.

i believe there is some data showing that naturally it can some hepatotoxicity

In adults and adolescents, hepatotoxicity may occur following ingestion of greater than 7.5 to 10 g (ie, 24 regular-strength or 15 extra-strength caplets or tablets) over a period of 8 hours or less. So, the pain may not be related to your medications. Hope this helped and do keep us posted.

Viagra has some side effects, including hepatotoxicity, acute liver injury. It seems not useful for liver, damaged by HCV. See http://livertox.nih.gov/Sildenafil.

Alcohol consumption has been associated a higher risk of developing isoniazid-induced hepatotoxicity. Isoniazid should be eliminated from your body about 20-24 hours after your last dose.

As for the two doses, studies indicate that 28 days is required to give the maximum benefit. Side effects I would suspect will be minimal. Truvada carries a risk of hepatotoxicity but this is not a concern after two doses. Your risk is fairly low so take a 4th Gen Duo test at 28 days to give you some relief.

Choanal and esophageal atresia of fetus in MMI-treated and maternal hepatotoxicity in PTU-treated pregnancies are of utmost concern. Maintaining free thyroxine concentration in the upper one-third of each trimester-specific reference interval denotes success of therapy. MMI is the mainstay of the treatment of post partum hyperthyroidism, in particular during lactation." http://www.ncbi.nlm.nih.gov/pubmed/21389085 IIRC about 30% of women have thyroid enlargement during pregnancy.

There are many choices for anxiety and it takes trial and error to get the right combo. I suggest Nefazodone (Serzone) in a light dose at first, ramp to 150mg BID, Serzone doesn't have any any of the side effects of Paxil. There are known liver side effects for Serzone though and must be carefully considered with current liver function + follow liver functions while on it.

Nefazodone hepatotoxicity

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serzone