It could indicate an allergic reaction. It could be
Angioedema, which is swelling of the deeper layers of the skin. The swelling is often severe and is caused by a build-up of fluid. The symptoms of angioedema can affect any part of the body. Many people with angioedema also have another condition called urticaria, which is also known as hives. This is a raised, red and itchy rash that appears on the skin. Angioedema is of four types allergic, idiopathic, drug induced and hereditary.