Morphine metabolites

Common Questions and Answers about Morphine metabolites

avinza

Do norco fentanyl and morphine create the same metabolite in urine tests?
If you have gastro paresis can it make your drug test negative for morphine but your actually taking morphine?
When I moved to Mexico three years ago methadone was available, but it has recently (six months ago) been replaced by morphine, so I have been taking morphine since then. While morphine does seem to reduce my pain, it is not effective in affordable quantities. I go through about 400 30mg tabs a month. Curiously, methadone, one of the worlds least expensively manufactured drugs is twice the price of morphine here in Mexico.
However you must keep in mind that codeine is a prodrug. It's main metabolite is Morphine. Some of these metabolites can remain in your system in low traces, for upto 72 hours. It all depends on your dosage.
Yes, it is quite common to get false positive oxycodone test when you are being tested for hydrocodone. This is because there are some morphine like metabolites which may be common to both. You need to talk to your doctor regarding this. Take care! The medical advice given should not be considered a substitute for medical care provided by a doctor who can examine you.
Normetabolites on drug testing such as norcodeine are unique metabolites. This means you cannot get them until you consume a drug that has norcodeine. MS-contin contains morphine sulfate. So, its metabolite can be normorphine but not nor codeine. Hence your doctor may be suspecting that you are taking norcodeine or a similar drug. Take care! The medical advice given should not be considered a substitute for medical care provided by a doctor who can examine you.
Codeine breaks down into morphine. The opiate drug tests look for codeine, morphine, and 6-acetyl-morphine. The presence of 6-acetyl-morphine is relatively conclusive of recent heroin use, but is only detectable for a few hours after use. The presence of codeine can be the result of either heroin or codeine use. The presence of morphine can be the result of the use of heroin, codeine, or morphine. Relative levels of codeine and morphine can help determine their origin.
Can Vicoden show up as traces of Morphine in a UA? Son had a UA that came back dirty with traces of morphine showing up. He was on Vicoden for a broken bone a while before and swears upside down and sideways he had not taken anything other than the Vicoden. What else would show up as Morphine? Where can we find info on this? Am I being strung alone or does this have any merit?
For ease of use, the detection times of metabolites have been incorporated into each parent drug. For example, heroin and cocaine can only be detected for a few hours after use, but their metabolites can be detected for several days in urine. In this type of situation, we will report the (longer) detection times of the metabolites. NOTE 1: Oral fluid or saliva testing results for the most part mimic that of blood. The only exceptions are THC and benzodiazepines.
Fentanyl is in the same class as Morphine, however, it is synthetic and does not metabolize like other opiates, ie Vicodin, Morphine, Codeine. The urine test is testing for metabolites, ie norhydrocodone, hydromorphone. It depends on the test that is being used and that the assay cutoff is for that particular test. The test for Fentanyl is specific to look for that drug and a normalized value can be detected usually 3-4 days after.
for example a 10 Panel looks for marijuana, cocaine, phencyclidine, opiates, methamphetamine, methadone, amphetamines, barbituates, benzodiazepines and trycyclic antidepressants. The opiates is a panel that detects opiates such as heroin, morphine, codeine and synthetic pain relievers like oxycodone and hydrocodone can be detected for 1 to 4 days, depending upon the form, its metabolites and amount and duration of use. So, I believe it will show up the same...
The average plasma half life ( half the time a chemical takes to be metabolized and leave the body) is 3.8 hours. Most opiates like morphine, codeine, and heroin are detected up to 2 days after taking the drug in urine, up to 90 days on hair, and 6 hours in blood except for codeine which can be detected up to 12 hours after. NIDA, however, legally prohibits the reporting of the 3 metabolites of hydrocodone.
, codeine, hydrocodone, meperidine, methadone, morphine, propoxyphene) have active metabolites that are further converted to inactive substances....." Opiates can cause liver damage, some more than others. I wish I had better information for you. I encourage you to discuss this with your physician. .... and Please let us know how you are doing and what you discover. Feel free to post again and ask additional questions. We are Chronic Pain Patients... and get it!
The metabolism of each opioid leaves traces of metabolites and other chemical byproducts. By assaying the levels of these substances in the blood or urine, the lab can determine, with some degree of certainty, which particular medication you're using -- codeine, oxycodone, morphine, hydromorphone, etc. However, these tests can be wrong because of differences in our individual ability to make specific enzymes for the metabolism of these medications.
Although methadone and fentanyl are also heavily protein bound and as such require reduced dosing in patients with cirrhosis, the metabolism of these agents does not yield toxic metabolites, and hence they, along with hydromorphone, may be better tolerated37,38 (Table 2)." ".....Hydromorphone and fentanyl appear to be the least affected by renal dysfunction, and fentanyl has less hemodynamic disturbance (due to lack of histamine release associated with other opioids).
Trazodone. Trazodone will inhibit opioid metabolites from showing in your urine. I can't believe it. I take 100mg of trazodone every night for sleep, so when my doctor took my urine, tah-dah, no opiates. Upon further research it would seem that it does not affect the analgesia of morphine or oxycodone. Therefore the fact that ms contin doesn't help me with my pain is all me and my silly body. So, for all of my friends out there, we have all learned an interesting lesson.
I explained to my doc that #1 Whenever I have been in the hospital or in any traumatic incident that required the administration of morphine, the morphine never worked. It really felt like nothing was administered, and I'm talking about multiple injections. I would always end up getting administered fentanyl or dilaudid or both to dull my pain. I also cited the fact that 3 out of 10 caucasions have an inability to absorb and metabolize morphine. It is a well studied genetic mutation.
It's interesting because what they actually test for are metabolites (what the opioid breaks down into). Most common opioids break down into codeine, norcodeine, morphine, and normorphine. And that is what most tests actually look for. However, out of all the opioids, oxycodone and buprenorphine are both semi-synthetic thebain derivatives and do not turn into those metabolites. (Thebain is just a minor chemical constituent of opium by the way.) And surprise, surprise...
Also, codein comes up as a Morphine Metabolite in a UA and Hydrocodone comes up as Hydromorphone metabolites So if the DR doesnt have knowlege of certain Opioid metabolites it could be seen as indicating abuse.(I dont think that peratins to either of you though) There was talk of false/positives which is why a secondary test is supposed to be done before the DR confronts a patient regarding UA results.
The primary metabolites of codeine are morphine, and codeine-6-glucuronide. Not only is codeine converted into morphine in the body, but also several other active compounds. The approximate distribution is as follows: codeine-6-glucuronide (~70%), norcodeine (~10%), and hydromorphone (~1%). Conversion of codeine to morphine occurs in the liver via cytochrome P450 enzyme CYP2D6.
, codeine, hydrocodone, meperidine, methadone, morphine, propoxyphene) have active metabolites that are further converted to inactive substances. The serum concentrations of these agents and their metabolites may be increased and the half-lives prolonged in patients with impaired hepatic function. Therapy with opioids should be administered cautiously and initiated at reduced dosages in patients with liver disease.
A problem is that these methods sometimes can be too good, detecting small amounts of irrelevant agents or metabolites that are diagnostically unhelpful or confusing. While it would be presumptuous to caution against the use of urine drug monitoring, there are a number of potential pitfalls worth noting.
Although available for decades, its use has gained renewed interest due to its low cost and potential activity in neuropathic pain syndromes. Unlike morphine, methadone is a racemic mix; one stereoisomer acts as a NMDA receptor antagonist, the other is a mu-agonist opioid. The NMDA mechanism plays an important role in the prevention of opioid tolerance, potentiation of opioid effects, and efficacy for neuropathic pain syndromes, although this latter impression is largely anecdotal.
Investigation of the mechanism responsible for the morphine action revealed that morphine inhibited expression of IFN regulatory factor 5 in the hepatocytes. In addition, morphine suppressed the expression of p38, an important signal-transducing molecule involved in IFN- alpha -mediated anti-HCV activity. These findings indicate that morphine plays a cofactor role in facilitating HCV persistence in human hepatocytes.
For example, patients prescribed only codeine might test positive for codeine and morphine, and also hydrocodone and hydromorphone. Patients taking only morphine might also test positive for hydrocodone and/or hydromorphone. While mechanism behind this metabolic phenomenon are not understood, such findings could falsely suggest that patients are taking unauthorized opioids.
The major discovery is that the classic opioids like morphine, oxycodone, fentanyl, and Dilaudid (hydromorphone) break down into metabolites that are 'hyperalgesic', that is, molecules that can actually cause pain when they accumulate under conditions of chronic administration. This might explain the experience of switching to more and more potent opioids which in turn produce more and more hyperalgesic molecules, and so a vicious cycle develops. Methadone is different.
it is due to them having an inefficient version of the gene responsible for metabolising codeine metabolites into morphine. Some people of arab descent have the opposite problem; they are ultra metabolisers of codeine, and may risk death if they take a standard panadeine. It may also be that the clinic didn't give you a strong enough dose given the nature of the pain. It is a bit hit and miss, unfortunately.
A few years ago I had a doctor ask me how long I had been taking morphine/opiates for, and what kind of pain was I in where I would risk taking them while being pregnant...I was in shock! I told him that I don't do drugs...he said that the blood work doesn't lie. It wasn't until another doctor in the same clinic ( who heard me freak out ) told him that ingesting poppy seeds ( even the small amount on a bagel ) can give a false positive, that he believed me.
This is so because at times the dose taken on the day of the test is often not able to generate the required metabolite by the time the test is taken. Also the metabolites generated by previous day’s dose are often washed away in urine or are too low to be detected by urine test. In these cases blood test and hair test are more accurate. However, urine tests are cheaper and hence more widely used. You could ask your doctor whether blood or hair test could be done in your case. Take care!
For instance, oxycodone is metabolized into oxymorphone before it reaches the brain. Heroin is metabolized into morphine, these are one of the metabolites looked for in drug tests.Levmetamfetamine ( in vicks inhalers) can cause a false pos. for methamphetamine. Pseudoephedrine can also cause a false positive but the concentration of the metabolites in the urine needed for a positive would probably be fatal. It sounds more like human error being that you tested negative right afterward.
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