Narcotic Analgesics (Includes Oxycodone) ↔
Liver Disease
Severe Potential Hazard, High plausibility
Applies to: Liver Disease
Narcotic (opioid) analgesic agents are extensively metabolized by the liver, and several of them (e.g., codeine, hydrocodone, meperidine, methadone, morphine, propoxyphene) have active metabolites that are further converted to inactive substances.