Morphine and liver
Common Questions and Answers about Morphine and liver
avinza
so I just researched the oxy, the vicodin, and all the rest...as they relate to the liver AND fibrosis and/or HCV....and the more I read......the more scared I got.
SO, so far, the literature is suggesting more increase in fibrotic activity,
I'd be reluctant to say any pain medication is "liver friendly" at this point.
Even though everyone keeps parading that same tired standard "two grams a day of tylenol is safe for liver patients"....
Second, if the source of your pain can be managed or eliminated then you can proceed with stopping the morphine. Morphine is an opiate pain killer that can be highly addictive. You should get help weaning yourself off of the drug. Coming off of the morphine will be difficult after 3 years of use. I would seek help from a doctor that specializes in drug addiction or find a pain clinic at a hospital that is experienced weaning patients off of addictive drugs.
Quite a risk of addiction, if you ask me, especially considering the long acting release and the potential for abuse
Someone said that OTC drugs were safer for the liver. Tylenol can be obtained OTC and is deadly to the liver if taken in too large a dose. The NSAIDs (ibuprofen, naproxen sodium, etc.) are bad for the kidneys and also the liver if you have hepc.
Like mammaglow, I am also on the Morphine ER and lesser immediate release tabs that I take in between. I am in my 8th week of treatment and my doc says that the Morphine is fine to take. I think one of the things to watch for is that alot of pain meds have alot of acetaminophen in them and that in high doses will affect the liver. If you need to be on pain meds try to get something that is more of the straight meds and have less of the additives that will affect the liver.
I took ZanaFlex for 4 months and had a rise in my liver enzymes from always being around 15-20 to a AST, 44 and a ALT of 60 after 5 weeks I was retested and my liver enzymes went to AST of 33 and ALT 52 , My Question is how long until I can expect until my liver enzymes return to normal and I don’t drink alcohol and do not have Hepatitis or HIV, my other liver function is all normal should I get a ultrasound?? How much damage did this drug to for 4 months??
Your gonna fry your liver unless you cold water extract those. Codeine is kind of a week opiate and you can only take so much before you acheive a ceiling effect (as in no more will get you higher). The mechanism of action is hepetic (liver) where in aproximately 15% per MG of codeine is converted to morphine. I believe the max amount of codeine the average liver can process is around 300-400mg of codeine which MEANS at the very worst you are on the equivilant of 60mg morphine.
I am now left out on a limb and being treated like I am a liar and a drug addict. What would give me a false positive for morphine and a false negative for xanax? I feel like they messed up the test and it is someone else's. Been in panic attack mode since talking to him today and only have 4 xanax left.This test was done 2 weeks ago and he just called me today and said he will not give me any more xanax because I tested negative for them.
Hi I was on Lortab tens for 8 yrs I have had a new dr and she is great for the last 9 yrs along the way she changed me to morphine 50/2mg E/R capsals twice a day (every 12 hrs)I know that loratab has Tylenol at a dose of 325mg and Tylenol goes thru your liver but what about morphine I was told it goes in to my blood stream is this true I had liver cancer in 1981 so I am trying to protect my liver and I have stage 3 kidney disease on the low end of stage 3 I also take flexeril 10 mg 3 a day but I
I have been very sick for the past few years. I have chronic abdominal pain and have been taking time release morphine as well as Norco for pain. Currently I am on 150 mg twice a day of morphine and approx 10 norco's a day. I would like to cut out the norco mainly because I have liver problems on top of everything else and I want to see if stopping the norco could help my organs function better. I have a lot of doctors and am also seeing a few specialists.
Light microscopy revealed severe centrolobular congestion and focal necrosis in the liver of morphine and tramadol groups, but perivenular necrosis was present only in the morphine group. The main histopathologic finding was vacuolization in tubular cells in morphine and tramadol groups. Our findings pointed out the risk of increased lipid peroxidation, hepatic and renal damage due to long term use of opioids, especially morphine.
It would seem to me that if absorbed through your skin it would be less likely to effect your liver. One of our members has a liver disorder and is on the Fentanyl Patch.
I also understand and like your screen name "Missin_life". Chronic pain can certainly make us feel that way. I hope you will find ways to change that feeling.
And please stay active in our community. We all learn from one another and do our best to support one another.
Narcotic (opioid) analgesic agents are extensively metabolized by the liver, and several of them (e.g., codeine, hydrocodone, meperidine, methadone, morphine, propoxyphene) have active metabolites that are further converted to inactive substances. The serum concentrations of these agents and their metabolites may be increased and the half-lives prolonged in patients with impaired hepatic function.
My brother is 46 and has been an alcoholic for many years. 2 years ago when he had his first seizure and went into the hospital he found out he ha end stage liver disease. He was given 6 months to live, that was 2 years as, he never stopped drinking or took any of the medication.
3 for stomach issues and they gave me 2 30 mg. morphine twice a day and 2mg dilaudid twice a day. That seemed ok but was in hospital. Well when I went to see primary dr. Told her how the hospital did the meds, she wanted to try that. So I tried for 2 weeks and worked ok and now she wants me to take. 3 30 mg. IR morphine just 3 a day and 2 dilaudid a day. I also wear fentanyl patches 100 mcg/h. And 50mcg/h. Change every 72 hrs. Ok with me changing the morphine will it put me into withdrawals?
During the process of discovery, I was taking Tylenol or Advil every four hours as directed for pain (approx 3 week period). After checking liver, kidney and ck levels, my doc gave me a perscription narcodit which included a small dose of tylenol. At that time my CK level was 4000. I was rechecked a week later. My levels rose to 5000. My doc immediately took me off the meds and gave me a morphine script. I will get a recheck to verify that the levels are going back toward normal.
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