Problem started while I was taking minocycline for
acne. Went in to student health. NP RXed 10 days
doxycycline, 100 mg PO BID, sent me to ER. Had an ultrasound, confirmed it was epididymitis plus a hydrocele. They gave me a shot of ceftriaxone and told me to continue with the doxycycline. The ceftriaxone helped a great deal (swelling went down almost immediately) but as I continued the course of doxy the problem began to get worse again.
I followed up with a urologist.