In more severe cases, oral antibiotics (such as tetracycline, doxycycline,
minocycline, or erythromycin) may be required.
Perioral dermatitis is a difficult condition to treat effectively. It often requires several months of treatment. It is not unusual for the bumps to return, particularly if skin creams containing steroids are reapplied to the face.
Temporarily there might be immediate relief with the steroid creams, but in the long run, it might causes recurrence of symptoms.