It affects mainly the thumb, index
finger,
middle finger and some times the palms as well. A common factor in developing carpal tunnel symptoms is increased hand use or activity.
Physiology and family history may have a significant role in individual's susceptibility. CTS is associated with stress, trauma, pregnancy, as well as several diseases including multiple myeloma, amyloid, rhematoid arthritis, acromegaly, mucopolysaccharidoses, hypothyroidism.