methadone kinetics

In light of the effect of opiates on HCV replication and immune responses, it is clear that studies on viral kinetics during methadone therapy are warranted to ensure comparable responses to current regimens in patients with ongoing opiate use.

bupe has a ‘ceiling effect’ that is responsible for its usefulness for addiction, and the writer was assuming ‘linear kinetics’. In reality, 1 mg of bupe equals 15 mg of methadone; 2 mg of bupe equals 30 mg of methadone, and 4 mg, or 8 mg, or 16 mg of bupe also equal… you guessed it… 30 mg of methadone! so anyway after a certain point sub just "ceilings out" and no longer can cover a super high addiction. with this being said..

3 cm in diameter, with slow progressive benign type enhancement kinetics (type 1 curve). I have another MRI next month (which is 8 months later- they forgot to schedule it at 6 months). My doctor states that I am higher risk then normal and I have also found another lump since then. I had a rough few months with all of the testing I did before and I am assuming the area of concern is the 4:00 position...

Hi Tim, While previous studies with peg-interferon (PegIFN) based therapy demonstrated that early viral kinetics could help to predict SVR rates this is not the case with Sovaldi + Ribavirin treatment. Treatment with non-interferon based treatments work differently than previous interferon based treatments so what applied to interferon based treatments RVR, eRVR, EVR are no longer applicable. In other words...

The mean half-life for multiple doses in the body is about 12 days, but very long-term kinetics are dominated by the kinetics of RBCs (half-life 40 days). RBCs store ribavirin for the lifetime of the cells, releasing it into the body's systems when old cells are degraded in the spleen. http://en.wikipedia.

Microarray analyses have shown that ribavirin increases induction of interferon-stimulated genes. We evaluated viral kinetics, serum cytokine expression, and viral mutagenesis during early stages of peginterferon therapy with and without ribavirin.

thank you once again stef for the swift update.

The mean half-life for multiple doses in the body is about 12 days, but very long-term kinetics are dominated by the kinetics of RBCs (half-life 40 days). RBCs store ribavirin for the lifetime of the cells, releasing it into the body's systems when old cells are degraded in the spleen.

The mean half-life for multiple doses in the body is about 12 days, but very long-term kinetics are dominated by the kinetics of RBCs (half-life 40 days). RBCs store ribavirin for the lifetime of the cells, releasing it into the body's systems when old cells are degraded in the spleen.

steady peintf levels are reached only between 5th and 8th week so you can only expect a decline kinetics between 12th and 24th weeks, if no decline after the 24th week then we can assume there is no response

My MRI said a segmental non masslike enhancement in the outer lower right breast with washout kinetics. What does that mean? Today the radiologist doing my biopsy said it might just be vague dense tissue with asymmetric edges , there were also cysts present any idea? I'm 42 and my left breast is riddled with papillomatosis.

We plan to test the doxycycline formulation to develop different release kinetics and delivery methods. For example, a slow release patch could be used in conjunction with current recommended protection against ticks, such as repellents and personal tick checks.

I asked my doctor for pegasys over peg intron. He addressed my concerns and told me sx's for me would be similar with either drug and kinetics were similar for both with regard to initial suppression of the virus. I had read about peaks and troughs with peg intron. He said that was dated info. Ok, so we decided to stay with peg intron. Now...about dosage. Can anyone explain why pegasys is one dose fits all and peg intron is weight based? I will get 80 mcg with weight at 114 lbs.

hbvdna is correlated to vitd levels, the higher vitd25oh, the lower intact pth, the lower hbvdna so yes it is best to keep levels 80-100ng/ml because levels normal at 30ng/ml are only for healthy people and for calcium kinetics and not for immune boosting effect/cancer prevention

I have gastroparesis, and GERD, and am on methadone maintenance. I noticed I started having problems as soon as I started the Methadone Clinic, 3 yrs ago. I recently had an endoscopy and waiting on the biopsy results. I'm so sick of not being able to eat anything. I'm living off of oatmeal and can't over eat. But it's not over eating because I've been starving. I can only eat a small bowl of oatmeal before I take my methadone and then another small one for lunch.

the most important thing is test hbsag quant in iu/ml, hbvdna if truly inactive, after we have hbsag kinetics and hbv genotype pegintf is the only cure we have now and works to clear hbsag whenhbsag is very low 1000iu/ml or less

Does look like an interesting drug..excellent rvr numbers and interesting comments on viral kinetics..Still an early trial though a 2b, if not mistaken. If given time, I might be more inclined in wating on phase 3 trials. "on treatment viral kenetics were constitent across all 95 psi-7977 exposed subjects, with responses independent of IL28B genotype and other predictors of poor response to IFN" http://www.natap.org/2011/EASL/EASL_06.

Hi Trish, The doctor and his research teams developed this equation, specifically because, there was no others in existence using simple data that is easy to acquire, other than viral kinetics, and more importantly, because using viral kinetics is not very accurate in predicting Tx outcome. They set out to develop a more precise model to use , in conjunction with viral kinetics . The doctor that conducted it has been researching ... and ...

They once again have a small group and we will see what the SVR rate is when the numbers are tallied. We will also have a sense of viral kinetics; how fast the viral load drops and the effect of the kinetics on SVR rate. Do we know which dosage arm you were in? The 100mg of VX222 or the 400mg? I'd guess that tuning this form of TX will be the dosing and duration, maybe emphasis on the duration. We may here more on this at the Spring EASL; preliminary results. Very sorry Steve.

Methadone kinetics

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