It take opprox 5 days for your last methadone dose to leave your blood. It's still in
fat and bone marrow
, but it is okay to take sub at any dose of methadone, after 5 days. I know what 250mgs CT feels like, I am not sure it is humanly possible to endure it. I haven't met anyone yet who has done it.
So, if the methadone is messing with your head, like it did mine, then buprenorphine is an okay option, IMO. 250mgs of methadone, even with a taper is going to be pretty intense at 0mgs.