I have taken it back when I was 16 (now 24), and I stopped because of the
side effects. Since May, I really have had any side effects. I start with 500mg twice and day, now I am on 1500mg daily. I too have PCOS. As far as OPK, I have done the OPK for about 4 months. There are several times were I would get + opk. but Af would not come 16 or even 28 days later. On the box witht he strips they do say that some women with PCOS or taking Ferility Pill may have a false positive.