in that it is in no way shape or form synthetic or semi-synthetic, and there aren't very many filler ingredients
.. besides morphine and a few sulfates/colors. Also more natural than all of the other narcotics, percodan, percocet, endoset, loratab, vicodin, these have other unnatural substances that do not exist in nature, i.e. acetaminophen etc. And when abused, these drugs can cause all sorts of problems with the liver and so on.