t just target one system (
valerian and kava mainly target GABA, as benzos do but with milder action
and no addiction or withdrawal reported). An overall approach would combine relaxants with adrenal support with perhaps amino acids that affect serotonin. Again as to "most powerful," most would say California poppy is stronger than valerian, but makes people even drowsier, and opium, which is an herb after all, is even stronger still.