When I first started on Copaxone two months ago, I found the shots quite painful (stinging), and had some major site
reactions (redness, huge welts, bruising, lumps
). I followed a regular routine of warming the site first, swabbing with alcohol, injecting the med at room temp using the autoinjector, and then using an ice pack for 15-30 mins afterwards. After the first few weeks, the site reactions had improved quite a bit. I continued to follow this same routine.