Only people with cirrhosis or other platelet issues need to worry about
platelets dropping dangerously
low. 20,000 or less. Interferon causes all treating persons platelets to drop to some degree. Obviously the more platelets you start with before treatment, the higher the platelet count will stay.
For people with cirrhosis who want or need to continue treatment they can have a transfusion of platelets every so often or Promacta, a drug that raises platelet counts.