Lovenox renal dosing
Common Questions and Answers about Lovenox renal dosing
lovenox
Please note Tenofovir is principally cleared through the kidney and dosing adjustments due to renal impairment have not been clinically tested.
The followings are extracts from the label information for Tenofovir:
2.3 Dose Adjustment for Renal Impairment in Adults
Significantly increased drug exposures occurred when VIREAD was administered to subjects with moderate to severe renal impairment [See Clinical Pharmacology (12.3)].
I had an ablation last week and am doing well, but am very beat up (low energy, black and blue, sore throat from TEE and polka dot bruises from Lovenox). My question is how long a time period is it usual to be on Lovenox? My doctor has said a full month. From my research, other than pregnant women, for all other conditions it says 2 weeks or less. I can't take coumadin due to a severe reaction to it.
I am not aware that impaired renal function precludes treatment for HCV. I have read that kidney disease is a negative predictor of SVR but, so too are a lot of conditions yet people have overcome them. I have seen articles which discuss the plasma levels of ribavirin with renal impaired patients. The suggestion is that rather than weight base dose these patients the dose should be arrived at by considering GFR (glomerular filtration rate).
This is from Clinical Care Options @ http://tiny.
By "AGE" I'm assuming you mean a persons age in years. I don't believe age has anything to do with Janumet's "effectiveness" but age has a larger role with renal function. To make it clear for other readers, Janumet is combination of two drugs; Sitagiptin and Metformin.
This a brief from the Merck web site - makers of Janumet - Section 8.5 - Geriatric Use JANUMET.
I also have kidney damage from a bout of high blood pressure 4 years ago, and I am a frequent kidney stone former, so I am being watched carefully by a nephrologist too. I have renal panels frequently too. I was wondering if any of this could increase my stone risk. I was reading about the cytomel and stones. The nephrologist wants me to remain on the synthroid and cytomel.
I think it depends on some individual factors, particularly renal clearance of the drug. I found this information in the drug reference:
According to the manufacturer's tests, the drug reaches maximum serum levels between 15 and 44 hours after subcutaneous injection of a single dose. The mean elimination half-life is 22 to 60 hours (mean = 40 hours). So, I would expect that after 7 days (4.2 half-lifes) that the concentration would be about 5.5% (0.5^4.2) of the maximum levels.
My mom recently survived hypervolemic shock (BP under 4, lost more than 90% of blood) due to internal bleeding due to prescription of Zosyn & Lovenox after diarrhea. She was being treated for bacterial pneumonia. She is now in renal and hepatic failure with some indication of turn around on #s (bilirubin high, but may be due to hematomas' reabsorption), She has a Dobhoff providing nutrition as she was not eating well and thus was retaining fluid.
Glomerular filtration rate or its approximation of the creatinine clearance are measured whenever renal disease is suspected or careful dosing of nephrotoxic drugs is required. The normal ranges of GFR, adjusted for body surface area for males is 70 ± 14 mL/min/m2 (56-84) . Risk factors for kidney disease include diabetes, high blood pressure, family history and older age.
Take care and keep us posted.
I also have the same issue. My IGM first came back borderline and then the 2nd 2 tests were just slightly positive. I don't have any history of miscarriages. I'm on 40mg Lovenox a day and have been spotting brown blood for past 2 weeks. I have heard Lovenox causes bleeding. I don't think I need to be on Lovenox. My Rhemetologist said some docs would think Lovenox is necessary while other docs would think I wouldn't need Lovenox.
I was put on Lovenox and a baby aspirin 2 weeks prior to miscarrying. The Doctor seems to think that when we get pregnant again that I can get on Lovenox and baby aspirin when i'm 7 weeks pregnant and that the pregnancy will be a healthy succuessful one. I'm just wondering has anyone else had a successful pregnancy taking Lovenox? Just really nervous and have alot of questions now. Should I go ahead and take the baby aspirin now or wait? The Doctor says we can try again in October.
I am pregnant. Well 9 weeks to be exact. I am on lovenox because of blood clot. How about you? and how do you feel?
The last time I had Lovenox was one year ago and I was at 2.6 when I started the Lovenox. At that time I quit taking coumadin until after the procedure. The day after the procedure, I started up on coumadin and continued to taking the Lovenox until I was therapeutic again (between 2-3 INR).
You stated that you were worried about the AFib. I assume you were referring to AFib while you are off coumadin and on Lovenox. I wouldn't worry about that.
Anyone on Lovenox... Will the burning ever go away? Any advice of where to do the injections. My love handles are so soar and its only been a week.
So I'm going on a daily dose of Lovenox, and I have to have hydroxyprogesterone weekly. I'm getting nervous not so much for me but my fiancé. He takes great care of me and idk if it's hormones but now with baby #2 being a girl it's a risk I may genetically passed or will pass my high blot clot risk to her. What if she has miscarriage problems or risks having going into labor early. I worry about my son too- I just found this information out today.
Has anybody used the blood thinner lovenox? My doctor put me on it for the whole pregnancy. I just forbid out I was carrying 4 days ago. I'm very nervous because I've had 3 miscarriages before this.
There are preferred opiates drugs that are use in patients with liver disease that have shorter half-lives and have less harmful side effects on the renal system. Your liver doctor should be aware of these drugs and be able to determine if you may be able to use them.
With regards to OTC medications, normal recommended doses of acetaminophen can be safely given to patients who suffer from cirrhosis in the short term.
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