Lovastatin vs atorvastatin
Common Questions and Answers about Lovastatin vs atorvastatin
lescol
lovastatin, simvastatin, pravastatin, fluvastatin, and atorvastatin (cerivastatin was withdrawn from the market by the manufacturer in August 2001). The major effect of the statins is to lower LDL-cholesterol levels, and they lower LDL-cholesterol more than other types of drugs. Statins inhibit an enzyme, HMG- CoA reductase, that controls the rate of cholesterol production in the body.
Virtually all patients taking a statin were on simvastatin (n=25); 2 were on lovastatin, 2 on atorvastatin and 1 on fluvastatin.
The pooled SVR rate* for the 104 patients on standard treatment was 37%. This is the highest SVR ever reported in the medical literature for a VA based population.
The pooled SVR rate for the triple therapy group was 63%. In terms of HCV subgroups, the effect was statistically strongest for genotype one, the most difficult subgroup to treat.
• atorvastatin (Lipitor)
• fluvastatin (Lescol)
• lovastatin (Mevacor)
• pravastatin (Pravachol)
• simvastatin (Zocor)
With increasing rates of obesity and associated metabolic conditions – both in HCV positive individuals and in the population as a whole – the statins have become one of the most widely prescribed classes of drugs
Statins and HCV
In the July 2006 issue of Hepatology, M.
A retrospective analysis of 104 patients with hepatitis C who received PI+R versus 30 patients who received PI+R plus a statin (simvastatin, n=25; lovastatin, n=2; atorvastatin, n=2; or fluvastatin, n=1) was conducted to measure sustained viral response rates. Overall, a pooled analysis demonstrated a 63% sustained viral response among patients receiving PI+R plus a statin versus a 37% sustained viral response among patients receiving PI+R only (P=.009).
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Uses, Side Effects, Precautions and Interactions
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