At this time, there are no warfarin
substitutes approved by the FDA for <span style = 'background-color: #dae8f4'>use</span>
with mechanical valve patients. There are some anecdotal accounts of
the newer anticoagulants' having been use
f-label for this, with disastrous results. I think it will be a while before we see a good warfarin replacement for mech valve patients. The newer anticoagulants that are out now are being use
d for other indications, like atrial fibrillation, deep vein thrombosis, and post-orthopedic surgery.