Sorry to hear about your symptoms. Unfortunately, Vincristine is well known to cause pretty severe PNs. Don't know what you;ve tried but I can give you a list of things that we used here. First, capsaicin cream
(over the counter
) burns when you initially apply it, but is supposed to "burn out" the
pain fibers giving you some relief. lidocaine
patches and combo ketoprofen/ketamine patches have also been helpful to some patients.