After prolonged administration, abrupt cessation of
treatment may produce nausea, headache, and malaise. Gradual dosage reduction has been reported to produce, within two weeks, transient symptoms including irritability, restlessness, and dream and sleep disturbance.
These symptoms are not indicative of
addiction. Rare instances have been reported of
mania or hypomania occurring within 2-7 days following cessation of
chronic therapy with tricyclic antidepressants.