Occasionally, these symptoms, if severe, may signal an allergy to benzoyl peroxide, and
often include swelling, itching or tenderness
. Dilute an over-the-counter, cream-based hydrocortisone cream with a little water to treat existing irritation. Allergy aside, the skin will adjust to benzoyl peroxide over a period of a few weeks. A proteolytic enzyme, Enzyme Exfoliating Masque Celazome, used as an exfoliant will temporarily remove flaky skin.