Saphris and Seroquel are both in the atypical antipsychotic family, while
Lamictal is in the anti-epileptic family.
Lamictal is good if depression is your main issue, and it has one of the best side effect profiles of any of the mood stabilizers. It's what I'm on, and so far it seems to be working pretty well (I've gotten up to 100 mg). I haven't taken any atypicals. If he's giving you a choice, my vote is for Lamictal.