Wellbutrin being an anti-depressent can sometimes worsen mania in
bipolar. Lithium is highly effective but
for some people can cause cognitive blunting
and sedation. With antipsychotics, the newest ones Abilify, Fanapt and Saphris have less of a potential of weight gain but as they can change heart rhythms you would have to ask your psychiatrist if they could be used safely if you have heart valve problems.