I had a lot of extrahepatic manifestation prior to treatment (including pretty severe fatigue and no energy, back pain and spasms, hip and knee
pain, other joint
pain, creeping glucose levels, astham, allergies, and many others. I also had wrist pain, similar to yours but that is gone now. Since Tx I have zero fatigue, tons of energy, no back pain, decreasing glucose levels, no problem with asthma, allergies better, and a lot less joint pain and aches.