Januvia and renal impairment

Common Questions and Answers about Januvia and renal impairment

januvia

Avatar f tn These dosing interval recommendations are based on modeling of single-dose pharmacokinetic data in non-HIV and non-HBV infected subjects with varying degrees of renal impairment, including end-stage renal disease requiring hemodialysis.
Avatar f tn New Onset or Worsening Renal Impairment Tenofovir is principally eliminated by the kidney. Renal impairment, including cases of acute renal failure and Fanconi syndrome (renal tubular injury with severe hypophosphatemia), has been reported with the use of VIREAD [See ADVERSE REACTIONS]. It is recommended that creatinine clearance be calculated in all patients prior to initiating therapy and as clinically appropriate during therapy with VIREAD.
Avatar m tn It is likely the patient had acute colchicine toxicity brought on by the addition of erythromycin and superimposed on chronic colchicine intoxication secondary to renal and hepatic impairment. The patient improved with supportive therapy and intensive hemodialysis and was discharged on day 70 of hospitalization. Another report describes two fatal cases of agranulocytosis due to presumed interaction between colchicine and clarithromycin, a potent CYP450 3A4 inhibitor.
Avatar n tn I take (2) 500mg of metformin at breakfast and supper. I also take powder welchol at supper. I would like to take my 1000mg of Januvia at bedtime to help lower my morning blood sugar readings that usually run in the 150's to 160, Any cons to taking the Januvia without food at bedtime?
1128488 tn?1265053382 AMPYRA is contraindicated in patients with moderate to severe renal impairment (CrCl≤50 mL/min); the risk of seizures in patients with mild renal impairment (CrCl 51–80 mL/min) is unknown, but AMPYRA plasma levels in these patients may approach those seen at a dose of 15 mg twice daily, a dose that may be associated with an increased risk of seizures; estimated CrCl should be known before initiating treatment with AMPYRA." (http://brassandivory.blogspot.
Avatar m tn Elevated levels may be seen in kidney disease, muscle degeneration, and some drugs involved in impairment of kidney function. The normal values of serum uric Acid are 3.0 - 8.2 mg/dL.A normal BUN-to-creatinine ratio is between 10 to 1 .Your values seem to be in normal range. It is suggested to discuss your test results with your attending doctor and correlate them clinically. I sincerely hope it helps. Best wishes and kind regards!
Avatar n tn i m asking as haw the use of sitaglipin help in conlrolling the sugar levels.
Avatar m tn 96 and now at 1.43. He has no renal impairment and his kidney ultrasound and detailed urine report is perfectly normal. He is cirrhotic (Hep-c) at stage 2 according to doc (hep-c) which stopped the sovaldi + ribavirin treatment to save his kidneys. However during the period he was also on diuretics (furosemide) occasionally. His nephrologist says that it is safe to continue sovaldi treatment but the other doc gave a red flag (I have yet to have a dicussion with the nephrologist).
Avatar m tn Sorry to be getting back to you after all these months. I am maintaining a stage 3 and was on a 3 month regiment of vitamin d and we also eliminated metformin. I take Amaryl now, instead.. My blood glucose was out of control but my PCP put me on Victoza. That seems to be helping with the exception of BS levels being very low in the morning. My PCP has suggested she might take me off the Amaryl and just have me take more insulin along with the Victoza and Januvia.
Avatar n tn The goals of pretransplantation HCV therapy are to decrease the risk for progression of HCV-associated liver disease, stabilize renal function in patients with HCV-related glomerulopathy, and prevent development of HCV-associated renal disease after transplantation.
Avatar m tn Hello, A clinical examination and work up is important for correct diagnosis and management.Fever, chest pain and congestion can be due to an infection like pneumonia. High fever can be a symptom of infection or septicaemia.Hypotension, hypovolaemia, angina all can cause chest pain. Since she is unable to walk a portable X-ray chest may be helpful. Blood tests and blood culture may be helpful.
1471082 tn?1286757000 Swelling of legs could be due to osteoarthritis, hypertension, renal impairment. So please consult your treating neurologist to have a look and refer you or suggest you to consult an orthopaedician if required. If he is already not taking, he may require treatment for agitation or aggressive behavior. Hearing aids, glasses or cataract surgery if appropriate. Behavior therapy might help by ignoring inappropriate and rewarding good behavior. Reality orientation may help reduce disorientation.
Avatar f tn While elevated ammonia levels are seen in cirrhotic patients there can be encephalopathy with normal ammonia levels and there can also be no mental impairment in some patients with elevated ammonia levels. Basically, ammonia levels are of limited use for diagnosing cirrhosis or hepatic impairment. I would also think some other results of your blood work would have been out of range if you are cirrhotic or are suffering significant liver impairment.
Avatar m tn An elevated BUN [blood urea nitrogen] is concern for liver and/or renal impairment, not diabetes. Although I have empathy for your father, you are seeking help in the wrong place. Ask your father's doctor to refer you to a nutritionist or some who specializes in that degree in your country.
Avatar n tn I would love to have those numbers.. i have to workout like crazy and eat very little to get close to those and thats also with taking another med with the metformin. I would say something is very wrong with what they are trying to do.
Avatar f tn The levothyroxine has a long half-life within the blood and may also be withheld for 3 to 4 days without significant changes observed. The Januvia and blood pressure meds you shouldn’t mess around with, so the experiment may not be performed completely. . While you may think the diet has nothing to do with it, but I think investigating would be better than pure recall. You could try to make a log of things she eats and again try to make changes there depending on which foods seem suspect.
Avatar n tn My father has mild kidney impairment from jump starting him after bypass. He takes lasix 80 mg BID and when his weight is up he takes 160 BID for 3 days. They have removed 1800 cc, then another 2 full bottles from the pleurovac (which I believe the bottle holds 600cc). Right now they are beginning aggressive physical therapy to see how he does then they will evaluate for other options.
Avatar n tn Been on januvia for a week. Blood sugar is not going below 120 ...and as high as 250. Was on glyburide. Had trouble with BS dropping as low as 40. Doc thought I would do better with this drug. I have only one kidney so was prescribed a 50mg dose. Will it regulate after I have been on for awhile?
Avatar f tn While in the hospital for heart related problems my doctors found that I had the D word. I refuse to accept this as I have worked so hard to avoid having the D word. I was sent home with a monitor which I refuse to use (no fear of needles just using the monitor means acceptance). I am on Januvia 50 mg and Amaryl 1mg. My doctor told me to eat 3 meals a day plus a snack at bed time. I have lived by the Atkins diet and don't eat carbs and don't care for sweets.
Avatar m tn Mannitol could be an issue since it is an osmotic diuretic agent and a weak renal vasodilator. The amount of mannitol in Copaxone is small and absorption Gabapentin (Neurontin) should be used carefully in patients with renal impairment due to possible accumulation and toxicity. It has been linked with liver toxicity. Provigil is metabolized by the liver and excreted in the urine. Have they looked for an independent cause?
Avatar n tn If these levels are unavailable (because the patient has been well and has had no blood tests) it is occasionally necessary to treat a patient briefly as having ARF until it has been established that the renal impairment is irreversible.