However this could be idiopathic (cause not known) or could be due to hypothyroidsm, hypoparathyroidsm, adrenal gland insufficiency, certain medications like cimetidine, corticosteroids, danazol,
isotretinoin, levothyroxine, lithium, minocycline, nalidixic acid, nitrofurantoin, tamoxifen, tetracycline, or ciclosporin, iron deficiency anemia, chronic renal failure etc. Similarly Empty Sella Syndrome can be a primary one or secondary one due to injury, radiation or chemotherapy.