Interferon ribavirin therapy

Common Questions and Answers about Interferon ribavirin therapy

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Avatar m tn Ribavirin improves the kinetics of the early response to therapy in patients with an adequate initial response to peginterferon. Induction of interferon-stimulated cytokines correlates with viral kinetics following ribavirin therapy, suggesting that ribavirin promotes interferon signaling. See: http://www.ncbi.nlm.nih.gov/pubmed/20303352 Ribavirin potentiates interferon action by augmenting interferon-stimulated gene induction Hepatology.
Avatar f tn She is on stage 3/4. I am not sure if this therapy (pegylated interferon, ribavirin and teleprevir) is the best options for her, but doctor says we should start with this..
5045042 tn?1365890100 Hi sorry to hear about your rash. Not many treating with interferon and ribavirin anymore since the new meds like Harvoni and Viekira Pak and now many others were approved since 2013 2014. Curious where are you located that you were treated with interferon. What advise has your doctor offered? You may be able to find some help in the post hep c treatment community forum http://www.medhelp.
Avatar n tn pegylated interferon and ribavirin PLUS either boceprevir or telaprevir You will be given a treatment regimen based in large part on your genotype. Genotype refers to the "strain" of hepatitis C virus that a person has. There are six genotypes. In the United States, genotype 1 is the most common, followed by genotype 2 and 3. People with genotype 1 generally are given triple therapy. People with genotype 2 and 3 are given dual therapy. http://www.hepatitis.va.
Avatar m tn After 12 weeks of the triple-therapy regimen, pegylated interferon/ribavirin only was continued for 0, 12, or 36 weeks; the control group received the current standard of care (48 weeks of pegylated interferon/ribavirin). Patients randomized to the treatment arms receiving 12 or 24 weeks of therapy were eligible to stop treatment if they achieved an RVR at week 4 and maintained this response at weeks 10 and 20. Otherwise, all subjects received a full 48-week course of therapy.
Avatar m tn HCV viral breakthrough is an ongoing possibility during the pegylated interferon/ribavirin continuation phase after triple therapy with telaprevir (Incivek or Incivek or Incivo), especially for difficult-to-treat patients, researchers reported this week at the Digestive Disease Week conference (DDW 2013) in Orlando.
Avatar m tn The standard of care for treatment of chronic hepatitis C is Pegylated Interferon injections once a week combined with daily Ribavirin pills. Interferon boosts the immune system to attack liver cells infected with hepatitis C virus and inhibits viral replication. Ribavirin has a broad-spectrum of antiviral activity and inhibits replication and infectivity of the virus.
Avatar m tn Therapy is one 150mg capsule of simeprevir once daily plus pegylated interferon and ribavirin for 12 weeks, followed by peg-interferon and ribavirin alone for either 12 or 36 weeks based on response-guided therapy criteria. Advantages of Janssen’s Simprevir therapy: - For all genotype 1s, either treatment naive or treatment experienced patients.
419309 tn?1326503291 Hi. The Interferon/Ribavirin is not being given to treat the liver cancer itself, but the viral hepatitis (either Hepatitis B or C) that caused the cancer. The Interferon/Ribavirin will prevent further transformation of virus infected liver cells into cancer cells, but will not have an effect on any cancer cells which may have remained after the liver resection.
Avatar m tn responders to [pegylated interferon/ribavirin] can achieve an SVR with [pegylated interferon/ribavirin/800 mg boceprevir], but response is dependent on residual interferon responsiveness." They added that, "Treatment failures to [pegylated interferon/ribavirin] with > 2 log10 viral drop at [week 12] may be good candidates" for triple therapy.
Avatar m tn However, the molecular mechanisms by which ribavirin enhances early and sustained virological response rates during interferon-based antiviral HCV therapy are still unknown. Several mechanisms including (i) immunomodulatory properties, (ii) inhibition of the inosine monophosphate dehydrogenase, (iii) direct inhibition of the HCV-encoded NS5B RNA polymerase, (iv) induction of lethal mutagenesis and (v) modulation of interferon-stimulated gene expression are currently proposed.
5111569 tn?1363753882 Patients should be instructed to use at least two forms of effective contraception during treatment and for 6 months after treatment has been stopped. Pregnancy testing should occur monthly during Ribavirin therapy and for 6 months after therapy has stopped. -------------------------------------------------------------------------------------------------------- For female patients: Do not take ribavirin if you are pregnant or plan to become pregnant.
1084115 tn?1385228589 Nevertheless, this viral kinetic parameter has been estimated comparing the viral kinetics in patients with interferon-α monotherapy and interferon-α plus ribavirin combination therapy (41, 42). If ribavirin mainly blocks viral production, estimated treatment efficiencies on blocking viral production should be higher in patients treated with combination therapy than in patients treated with interferon-based monotherapy.
26471 tn?1211936521 Although ribavirin (Rib) and interferon (IFN) combination therapy has become a popular modality for treating patients with chronic hepatitis C virus, about 50% of patients usually relapse, particularly those with genotype1b and high viral load. It has been shown that patients in whom viremia was eliminated in the early period after staring IFN therapy showed favorable outcome. Here we investigated possible mechanisms underlying differences in sensitivities to IFN therapy.
1084115 tn?1385228589 The decrease in platelet count was smaller among those receiving combination peginterferon/ribavirin therapy compared with those receiving only peginterferon, indicating that ribavirin appears to mitigate thrombocytopenia due to interferon.
Avatar m tn Previous studies have observed that cough occurs more commonly in patients receiving the combination of interferon and ribavirin compared to interferon alone, thus implicating ribavirin as the causal agent. Our data demonstrate that it does so by reversible enhancement of cough reflex sensitivity. Clinicians should be aware of this potential treatment-related effect, so as to avoid unnecessary and costly diagnostic evaluations seeking an alternative aetiology of cough.
Avatar m tn The treatment chart I got from my Dr. the other day was Incivek 6-2-10 Ribavirin 8 & 8 and interferon friday pm what ever I choose. So it looks the same except I have 12 hours between the Riba and you have 8. I dont know if that matters. Sure seems like a ton of pills so afraid I will miss something. I do have a question, well actually a ton of questions tomorrow but one is that I did hear that the Riba can affect your sleeping, and I cant have that.
Avatar m tn You could 1) treat now with triple therapy (Incivek or Victrellis, Interferon, and Ribavirin), 2) wait until the new treatments are approved and available, probably around Jan. 2014, and treat then (the treatment will be a new drug, Interferon, and Ribavirin), 3) look for a clinical trial for genotype 1's that is interferon free (trials have their own risks and you should study the pros and cons carefully), or 4) monitor the health of your liver regularly (every 6 mo to a year?
2090601 tn?1334515062 Until recently, however, most clinical trials have combined investigational DAAs with pegylated interferon/ribavirin standard therapy, which has suboptimal effectiveness and causes side effects that lead many potential patients to delay or refuse therapy. But several companies are now studying interferon-free oral regimens that combine DAAs that target different steps of the viral lifecycle; some also include ribavirin.