Initial hiv treatment regimen
Common Questions and Answers about Initial hiv treatment regimen
hiv
a phase 2b study of its interferon-free, investigational regimen for the treatment of hepatitis C (HCV). Initial results show sustained virological response at 12 weeks post treatment (SVR12) in 99 percent of treatment-naïve (n=77) and 93 percent of null responders (n=41) for genotype 1 (GT1) HCV patients taking a combination of ABT-450/r, ABT-267, ABT-333 and ribavirin for 12 weeks, based on an observed data analysis.
Daily daclatasvir (60 mg*) plus sofosbuvir (400 mg) for 12 weeks is a Recommended regimen for treatment-naïve patients with HCV genotype 3 infection who do not have cirrhosis.
Rating: Class I, Level A
Daily fixed-dose combination of sofosbuvir (400 mg)/velpatasvir (100 mg) for 12 weeks is a Recommended regimen for treatment-naïve patients with HCV genotype 3 infection who do not have cirrhosis.
3/22/2015 1/10/17 7/3/17 5/10/18 2/4/19
Reactive Equivocal Non-Reactive Non-Reactive Reactive
1:2 1:1 1:1
I keep shots of Penicillian sometimes 3 sometimes 1
//www.hcvguidelines.org/full-report/initial-treatment-hcv-infection-patients-starting-treatment
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INITIAL TREATMENT OF HCV INFECTION IN PATIENTS STARTING TREATMENT
V. Genotype 5 or 6
Few data are available to help guide decision-making in patients infected with HCV genotype 5 or 6.
5.5 Laboratory Tests
HCV-RNA levels should be monitored at Treatment Weeks 4, 8, 12, and 24, at the end of treatment, during treatment follow-up, and for other time points as clinically indicated. Use of a sensitive real-time reverse-transcription polymerase chain reaction (RT-PCR) assay for monitoring HCV-RNA levels during treatment is recommended.
I found an article on treatment of Hep C coinfection with HIV. It is new (2012) and is from AIDS info NIH. The article seems to indicate that the use of protease inhibitors in conjunction with Interferon and Ribavirin can be considered and done. If you cannot do triple medication treatment through your doctor, perhaps you can get into treatment at a large university affiliated medical center. Or, perhaps you can get into a study.
I'm confused first you mention you are taking Harvoni and Ribavirin for a week. Then you mention that your trying to decide whether to throw in 24 weeks of Riba with the Harvoni
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Did your doctor prescribe Harvoni and Ribavirin with option to discontinue RBV ? Did you add Ribavirin yourself?
WorriedMom and Hector provided correct current recommenced treatment either Harvoni 24 weeks or Harvoni plus RBV 12 weeks for INF/RIBA relapser, compensated cirrhosis.
However, we do not believe convenience is as important for an 8-12 week treatment regimen that produces a cure compared with for example chronic HIV treatment."
Shares of Enanta Pharmaceuticals Inc, which co-developed ABT-450 with AbbVie, were up 22.2 percent to $36.25 on Nasdaq. They are up more than 70 percent since AbbVie released data from the first Phase III trial last month.
AbbVie shares were up 2.1 percent at $52.30 in afternoon trading on the New York Stock Exchange.
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Both medications have proven efficacy when used as a component of a combination antiviral regimen to treat HCV-infected adults with compensated liver disease, cirrhosis, HIV co-infection, and hepatocellular carcinoma awaiting liver transplant. Clinical trials have shown that these new medications achieve SVR in 80%-95% of patients after 12-24 weeks of treatment.
Does chronic Hepatitis C affect only the liver?
At the same time, most people who get syphilis do not get HIV. Was a HIV blood test done at the time of your initial evaluation? If so and you had a negative HIV blood test at the time your syphilis blood test was positive, that is strong evidence you did not get HIV although further testing is recommended.
2. What would be your recommended screening/testing dates to know that I am not infected?
See above. A re-test for HIV is appropriate.
3. Am I overreacting?
I went to the doctor later that same day, and he did not seem very knowledgeable about HIV post-exposure treatment. He basically read me a few statistics and informed me that I have a 0.07% chance of contracting HIV even if the guy was positive. With such low risk, he said PEP is not necessary. Regardless, he prescribed me Truvada + Issentress for 28 days at my insistence.
Avastin is still not a standard treatment but, many doctors are using it as a follow up treatment, and there has been sucess in slowing the rate of recurrence. Avastin does not have the same side effects as chemo....I know someone that has been on Avastin for a recurrence for about a year or so and is doing very well. There are concerns with bowel issues and Avastin, but, everyone is different.
Wishing Lori the best of luck...
1 month ago, I did something very stupid, I mean I had receptive anal sex with a hiv-positive gay man with semen directly ejaculated into my anal. I knew it was very dangerous, and took prophylaxis medication within 12 hours after the exposure(about 12h). My regimen was Zidovudine+Lamivudine+Aluvia, bid. however, on the second day after my first dose, I missed one dose that night, and on the next day , I continued to take the regular dose.
It’s obviously best to remain 100% complaint with your treatment regimen, but we are human and prone to error. How many weeks have you done so far? There might be more leeway after the initial 12 weeks, or when one has become undetectable for virus. Discuss this with your doctor, so he knows what's up.
Recommended regimens for treatment-naive patients with HCV genotype 3 infection. 3 separate regimens:
Daily daclatasvir (60 mg*) and sofosbuvir (400 mg) for 12 weeks (no cirrhosis) or 24 weeks with or without weight-based RBV (cirrhosis) is recommended for treatment-naive patients with HCV genotype 3 infection.
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