8,,9 In addition to monocytes, keratinocytes
in skin were stimulated to produce cytokines.
Imiquimod upregulated IL-6 and IL-8
in vitro,3 while resiquimod induced mRNA for IL-1α, IL-8, TNF-α and transiently IFN-α.10
Peripheral blood mononuclear cell cytokine induction by imiquimod in vivo required tyrosine and protein kinase C activity, was independent of cellular protein synthesis and was mediated via the transcription factors NFκB and α4F1.