Anything you ingest by mouth is eventually going to go through your liver. From what I've read, ibuprofen isn't as hard on the liver as tylenol (acetomenaphen or paracetamol), but still be careful to take no more than what the label says, and tell your doctor you're taking it. If it works, your doctor may direct you to take more than what's on the label, but again, follow instructions, dosage and timing carefully. Stay away from the "extra strength" formulas.