It should not be used by anyone who may want to get on a transplant list. As drug or
alcohol abuse are conditions for not listing patients for
liver transplantation.
From the Mayo Clinic
"Major categories of pain medications, including over-the-counter analgesics (OTCAs) such as acetaminophen and nonsteroidal anti-inflammatory drugs (NSAIDs), as well as cyclooxygenase 2 (COX-2) inhibitors, anticonvulsants, antidepressants, and opioids, are largely metabolized by the liver.