s primary ingredient along with acetaminophen) is one of hundreds of older drugs that were introduced before 1962, when Congress passed a landmark amendment to the Food and
Drug Act that gave the FDA much more power to oversee safety
and efficacy
testing. But buried in a series of tests done in the 1930s are a number of troubling facts.
First, a primer: Hydrocodone was first manufactured in the early 1920s by the German pharmaceutical company Knoll.