Hello,
For the dark knuckles, treatment includes various skin creams like hydroquinone, azelaic
acid, corticosteroids, tretinoin
cream and laser treatment. However these should be used under a medical guidance. Also at night, repair your hands with creams formulated from glycolic acid—a must for improving skin texture and tone. For a more intensive nighttime treatment, apply cream and then cover hands with gloves or socks.