Ok, out of the 50,000 people in the trial,
how many continued to smoke,
how many were overweight,
how many were not exercising,how many were mostly eating crap..If you removed all those out of the group, then the beta blocker had little or no effect on the remaining people, except to maybe damage their kidneys.
I do not think there is an drug effectiveness than cant be trumped by lifestyle changes. I have a doctor friend who agrees that all drugs are just "damage control".