I think my depression stems from physical issues, so drugs can only do so
much for me, but it
does take away the lows I tend to feel. Good luck with it. One thing that did happen when I went on, and I don't know if this is related or not, but my blood pressure has been strangely low. I even fainted a few times. When I looked up side effects of Pristiq, I saw high blood pressure was a possible problem. I do agree that our Doctors don't know enough about this drug.