For me, the difference is unbelievable. I tried the whole CT thing before and had massive aches, anxiety, etc. This time, instead of a 10..anxiety, aches, pains have been maybe a 2-3. The diarrhea was terrible, and the occasional anxious feeling was bad, but tolerable. Nothing helps the tiredness and fatigue (in fact, the clonidine makes that part worse), but it's worth the trade-off.