I have never been on Premarin, which is a synthetic hormone (as I am sure you know) and was used quite exclusively for years for menopausal
symptoms. It was also the hormone
used in the big logitudinal study abruptly stopped in 2002... checking on the efficacy of womens hormones on the effect they would have on heart disease in women. The study was flawed from the start, however. And, even though I am not a Premarin fan at all, there are some women who do okay on it.